Report a relative proportion of patients ruled-out or ruled-in with a diagnostic test

One measure of the performance of a diagnostic test is the proportion of patients the test stratifies as likely not to have the condition (ruled-out:RO) or to have the condition (ruled-in:RI). This proportion depends on the prevalence of the... continue reading


MAOI and St John's Wort treatments for OCD may have a similar radical-based mechanism. Six years' unrelieved total compulsive thinking was cured by the MAOI Phenelzine, with also a role for radical-releasing phenols which enter the CNS very little... continue reading

Imagery in Rock and Ancient Art Influenced by Pareidolic Response to Environmental Stimuli

A Pareidolic Response to Environmental Stimuli occurs when it is triggered by a certain richly textured surface or object . This human trait is a result of a survival mechanism, where the environment is quickly scanned for potential threats. A... continue reading

Restricted SDM: Predicting habitat suitability from species occurrence only

Species Distribution Models are commonly used to predict species habitat suitability. The data needed to build such a model usually consist of a range of environmental variables together with a target variable - the species occurrence itself... continue reading

Microbial butanol tolerance: mediated by toxicity or by phase equilibrium?

It is conventionally assumed that the achievable concentration of a bio-alcohol molecule by fermentation is limited by the toxicity of that molecule to the micro-organisms producing it. In the case of ethanol, for example, extremely high titers... continue reading

A combinatorial approach towards treating cancer through Cisplatin

Cisplatin is an effective chemotherapeutic drug against a vast variety of cancers. It is a cytotoxic drug that kills cancer cells by forming DNA adducts, thereby damaging the DNA leading to apoptosis. However, the clinical use of cisplatin is... continue reading

A service to assess the quality of documentation of open source software

Could one build a service that checks the completeness and quality of documentation of an open source repository?

Potentially a group could build up a set of repositories with documentation ratings, which could then be used to train a ML/DL... continue reading

Effects of temperature on alcohol tolerance of microbes

It has been established that dissolution of membrane lipids plays a role in the toxicity of ethanol and butanol to micro-organisms; a matter of particular importance for the production of bio-alcohol fuels using fermentation by microbial activity.... continue reading

Bayesian verdicts

Why do juries emit binary verdicts, i.e. guilty or not guilty? Why not allow each juror to emit a "Bayesian vote" reflecting his/her subjective degree of belief in the probability of the defendant’s guilt? Under this alternative method of Bayesian... continue reading

Antibiotics indicating a link between migraines and gut bacteria

Recent research has found links between the composition of gut bacteria and whether a person suffers from migraines. Since [antibiotics influence gut... continue reading


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