Combinatorial therapy for chronic alcoholism
By Sukant Khurana, Srijoni Basu, Shail Adrian Jagmag
Chronic alcoholism forces the nervous system to be hyper-excitable as a result of homeostatic change that occurs in response to the constant sedative effects of alcohol. We propose a combination therapy targeting inhibitory neurotransmitters such as glycine and gamma-aminobutyric acid (GABA), along with ion channels, such as big potassium (BK) to counteract alcohol induced hyperactivity. Such a combinatorial approach can be of merit in various other neurological disorders.
Sukant Khurana, Srijoni Basu, Shail Adrian Jagmag
Published: 16 Sep, 2015