Combinatorial therapy for chronic alcoholism

By Sukant Khurana, Srijoni Basu, Shail Adrian Jagmag

alcohol drug discovery medicine inhibition ion-channels

Chronic alcoholism forces the nervous system to be hyper-excitable as a result of homeostatic change that occurs in response to the constant sedative effects of alcohol. We propose a combination therapy targeting inhibitory neurotransmitters such as glycine and gamma-aminobutyric acid (GABA), along with ion channels, such as big potassium (BK) to counteract alcohol induced hyperactivity. Such a combinatorial approach can be of merit in various other neurological disorders.

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