[{"id":152,"title":"Improving our knowledge on the host response to multidrug resistant bacteria.  A key towards combatting superbugs and developing novel host-directed therapies","sha":"ab728b67f16b258841a4a4152f16d62f","user_id":429,"state":"published","body":"Hospital acquired infections, mostly due to multi-drug resistant bacteria or “superbugs” are a growing concern and affects millions of patients every year worldwide. There is an urgent need to find novel treatment to improve the care of the hospitalized patients as bacteria are becoming resistant to all existing antibiotics. Unfortunately, there are limited resources to tackle these bacterial infections as the pharmaceutical industry has stopped developing novel antibiotics. This matter of urgency has been recently recognized from various countries (USA, UK…) and novel strategies are desperately needed. \r\n\r\nIn the general population, there are individual differences between humans that give some people an advantage in their ability to resist severe disease caused by infection. Similar to humans, some mouse strains or mouse mutants are resistant to bacterial infections.  \r\n\r\nThe idea would be to determine the genetic mechanisms of resistance to \"superbugs\" in mice. If we can determine what causes this resistance to multi-drug resistance bacteria, it then we may be able to improve existing treatments. We will also be in a position to develop novel host-directed therapies against superbugs that would target the host rather than the bacteria. This would control the infection and improve the treatment of the diseases. ","created_at":"2015-04-25T07:23:07.529Z","updated_at":"2023-02-07T09:20:56.050Z","zenodo_id":27964,"doi":"http://dx.doi.org/10.5281/zenodo.17159","subject":null,"tags":["superbugs","bacteria infection","antibiotics","host response","genetics","host-pathogens interations","host-directed therapies"],"vote_count":1,"view_count":1,"score":1.1,"deleted":false,"muted":false,"tweeted":true,"attachment_file_name":null,"attachment_content_type":null,"attachment_file_size":null,"attachment_updated_at":null},{"id":443,"title":"Antibiotics indicating a link between migraines and gut bacteria","sha":"c1d517c8f826edb8a5a6f56b1b60a2e4","user_id":null,"state":"published","body":"[Recent research](http://msystems.asm.org/content/1/5/e00105-16) has found links between the composition of gut bacteria and whether a person suffers from migraines. Since [antibiotics influence gut bacteria](https://www.sciencedaily.com/releases/2013/01/130109081145.htm), it is possible that they affect the occurrence of migraines.\r\n\r\nWe are aware of a recent case that seems to link migraines to antibiotics. The person was prescribed a course Doxycycline antibiotics. They had 3 migraines over the course of 5 days. While such an attack of migraines has occurred on occasions when antibiotics were not used, there seemed a very close link in timing of migraines and use of the antibiotics. The migraines occurred at different times of day, but all came within a few hours of taking the antibiotics. [Other people have experienced similar effects](https://treato.com/Doxycycline,Migraines/?a=s).\r\n\r\nGiven the widespread use of antibiotics there should be ample data to explore this connection between antibiotics, gut bacteria and migraines. The [American Gut project](http://americangut.org/) may provide a useful starting point.\r\n","created_at":"2018-02-27T20:03:36.430Z","updated_at":"2018-03-01T06:00:58.788Z","zenodo_id":1186460,"doi":"https://doi.org/10.5281/zenodo.1186460","subject":null,"tags":["antibiotics","migraine","gut bacteria"],"vote_count":0,"view_count":1,"score":0.1,"deleted":false,"muted":false,"tweeted":true,"attachment_file_name":null,"attachment_content_type":null,"attachment_file_size":null,"attachment_updated_at":null},{"id":191,"title":"Developed microbial communities in biofilm mode: the key for reinstating degraded ecosystems","sha":"544268b97815e94eb18a26e925a7f697","user_id":null,"state":"published","body":"In conventional scientific approaches, degraded ecosystems (e.g. conventional agroecosystems due to tillage and high doses of chemical inputs) are attempted to be revived mainly through nutrients, organic matter and water management. However, they do not provide a complete answer to the issue of sustainability of the ecosystems. It is now reported that sustainability of the ecosystems is an outcome of chemical signaling in the food web, in which microbes have got the central role to play (Seneviratne, 2015). Now, it is also known that developed microbial communities in biofilm mode and their exudates contribute more than their monoculture microbes in reinstating sustainability of the degraded ecosystems through increased biodiversity and ecosystem functioning.\r\n\r\nThe same concept can be applied to human body ecosystem. It is reported that the intake of antimicrobials like antibiotics is harmful to the human health. Sometimes, people use Probiotics after intake of antibiotics. They are mixtures of beneficial gut bacteria, but not in biofilm mode. Thus, in future medicines, developed microbial communities in biofilm mode and their exudates should be adopted for treating ailments. Then, they would help increase native biodiversity of gut bacteria, thus resulting in enhanced functioning of human body ecosystem for a healthy life.\r\n","created_at":"2015-07-15T14:05:09.570Z","updated_at":"2015-07-21T06:00:28.480Z","zenodo_id":37770,"doi":"http://dx.doi.org/10.5281/zenodo.20739","subject":null,"tags":["microbiology","illness","sustainability","antibiotics","drugs","crop productivity"],"vote_count":0,"view_count":1,"score":0.1,"deleted":false,"muted":false,"tweeted":true,"attachment_file_name":null,"attachment_content_type":null,"attachment_file_size":null,"attachment_updated_at":null}]