[{"id":78,"title":"Cancer cell nuclear expulsion: a possible mechanism of survival, and metastasis capability. ","sha":"b566367fae06afe6914bece416ea75cd","user_id":283,"state":"published","body":"A very interesting and novel experiment was carried out by Florina Bojin et al [Wiley](http://onlinelibrary.wiley.com/doi/10.1111/jcmm.12271/abstract). Constructing on this published work, I propose a novel survival mechanism of the cancer cell, and a new metastasis mechanism. Giving that cancer cells are known for their survival capabilities, could a nuclear expulsion -produced by stress, either biochemical, mechanical or nutritional- be used as survival mechanism, and, or a seeding action? The questions are many, but the answers could bring a new understanding of what exactly constitutes a cell or could a nucleus of of a cell -cancer cell- survive without its host cell? I propose a further investigation of the possibility that a cancer cell nucleus could be a seeding apparatus for metastases. Would a nucleus be able to ''high-jack''  another cell -if the nucleus survives the expulsion-? Is there an immune response to an ejected nucleus? I think the first steps are to confirm the existence of nuclear expulsion In Vivo, the viability of the ejected nuclei, and the possibility of ''nuclear cellular high-jacking''.\r\nThank you.     ","created_at":"2015-02-20T21:35:36.809Z","updated_at":"2015-02-26T11:52:06.861Z","zenodo_id":23227,"doi":"http://dx.doi.org/10.5281/zenodo.15562","subject":null,"tags":["science","cancer","molecularbiology","mechanism","cellular"],"vote_count":3,"view_count":1,"score":3.1,"deleted":false,"muted":false,"tweeted":false,"attachment_file_name":null,"attachment_content_type":null,"attachment_file_size":null,"attachment_updated_at":null},{"id":337,"title":"Soap bar skin scanner for detection of early melanoma","sha":"4895ad3c12c62341c73c11681dabf970","user_id":null,"state":"published","body":"Many scanners look inside the body, but none examine our whole skin because the ripples and folds of flesh need to be unfolded for camera access.  The current approach assumes no cooperation from the person being examined, except to lie or stand in standard positions. It struck me while showering that active participation by the person, in the privacy of their own washroom, could be invoked, because most of us will run a bar of soap over our whole accessible and not so accessible surfaces. My suggested design is then a checkerboard soap bar holder, with a smooth, exterior surface.  The squares would alternately allow the soap to contact the skin, and the other squares would be digital camera chips, for direct contact microscopy of the skin. Small LEDs could backlight nevi, allowing 3D lightfield imaging. After a shower or two, with appropriate montaging software, a map of our whole skin could be made and analyzed. Two such maps, 6 months apart, aligned and subtracted, could lead to detection of early melanoma: \"...most ultimately fatal melanomas are visible on the surface of the skin at a curable phase in their evolution\" (Weinstock, 2006). Melanoma incidence is rapidly increasing. See attached references.","created_at":"2016-09-20T06:00:01.780Z","updated_at":"2019-11-20T05:54:14.339Z","zenodo_id":154549,"doi":"https://doi.org/10.5281/zenodo.154549","subject":null,"tags":["imaging","microscopy","cancer","melanoma","lightfield","skin scanner"],"vote_count":2,"view_count":1,"score":2.1,"deleted":false,"muted":false,"tweeted":true,"attachment_file_name":"Gordon2016_Soap_References.pdf","attachment_content_type":"application/pdf","attachment_file_size":77556,"attachment_updated_at":"2016-09-20T05:59:59.982Z"}]