[{"id":834,"title":"Exhaled Nitric Oxide test for COVID-19 severity screening","sha":"6a9502033b8316e0fa63085ecb940901","user_id":null,"state":"published","body":"Exhaled Nitric Oxide (FeNO) testing is a widely-used diagnostic tool in the treatment of asthma, where it is used to estimate the extent of inflammation in the airways. Airway inflammation also plays a significant role in the disease progression of severe COVID-19 infections, which suggests that similar testing could play a role in determining the likely course that the disease will take in a patient. At present, the standard means of testing for COVID-19's characteristic inflammatory cascade is a C-reactive protein test, with rapidly rising CRP levels being a strong predictor of subsequent respiratory deterioration. A similar correlation with exhaled Nitric Oxide may exist, potentially offering an additional diagnostic tool that does not require a blood draw for laboratory testing. FeNO testing may also be predictive of otherwise mild COVID-19 cases that result in long-term lung damage.\r\n\r\n[A recent preprint](https://www.medrxiv.org/content/10.1101/2021.02.04.21251134v1) has shown that Budesonide, a corticosteroid used to treat airway inflammation in asthma patients and the prescription of which is frequently predicated on positive findings in FeNO testing, improves outcomes in COVID-19 patients, further highlighting a possible role for FeNO tests in the screening COVID-19 patients and in determining appropriate treatment options.","created_at":"2021-02-22T12:15:42.021Z","updated_at":"2021-05-21T06:01:19.694Z","zenodo_id":4775054,"doi":"https://doi.org/10.5281/zenodo.4775054","subject":null,"tags":["covid-19; lung damage; respiratory disease"],"vote_count":0,"view_count":1,"score":0.1,"deleted":false,"muted":false,"tweeted":false,"attachment_file_name":null,"attachment_content_type":null,"attachment_file_size":null,"attachment_updated_at":null}]