[{"id":877,"title":"Psilocybin treatment for cognitive impairment in Long COVID by way of restoring lost dendritic spine density","sha":"a184909209f25ad2155adcdf1e88faec","user_id":null,"state":"published","body":"Recent research has revealed a relationship between treatment-resistant depression and micro-structural changes in the brain, including lowered density of dendritic spines in several areas of the brain. Similar structural changes have been detected in the brains of recovered COVID-19 patients, and in-vitro studies have demonstrated that COVID-19 spike proteins can cause functional deficiencies in dendritic spine morphology in cultured neurons, suggesting dendritic spine deformation as possibly playing a causative role in the cognitive impairments associated with long COVID. \r\n\r\nPsilocybin has been found to stimulate dendritic spine formation in animal models of depression, resulting in micro-structural changes and prolonged improvement in stress-related behavioural deficits. Human trials with Psilocybin has also had positive results for treatment-resistant depression.\r\n\r\nPsilocybin, therefore, merits investigation as a treatment for the cognitive impairment associated with long COVID symptoms, with potential to stimulate recovery from micro-structural changes induced by the virus. ","created_at":"2021-08-23T12:29:54.829Z","updated_at":"2021-09-13T06:00:54.906Z","zenodo_id":5502228,"doi":"https://doi.org/10.5281/zenodo.5502228","subject":null,"tags":["covid-19","psilocybin","depression"],"vote_count":0,"view_count":1,"score":0.1,"deleted":false,"muted":false,"tweeted":false,"attachment_file_name":null,"attachment_content_type":null,"attachment_file_size":null,"attachment_updated_at":null}]