[{"id":225,"title":"Evolution in genetic terms – Is it RNA world or DNA world or is it anything else?","sha":"69b03c4db6269df0798781ef07244e59","user_id":null,"state":"published","body":"\r\nThe RNA world concept that self-replicating ribonucleic acid (RNA) molecules are keys to all current forms of life on Earth and geticists could not go further down might have missed out on how evolution has actually happened in real genetic terms. \r\n\r\nOut of all hypothesis and proposals, one that stands strong in the debate of “RNA before DNA” is \u003cb\u003e “protein synthesis can occur in the absence of DNA but not in the absence of RNA” \u003c/b\u003e. To contest this hypothesis, one should take a close look on life of an RNA molecule and their early degeneration process. \r\n\r\nEarlier RNA-protein interaction systems are highly doubtful because RNA is never a long-time informational molecule and even if they are or they used to be, many such information might got lost. Assuming this kind of unstable molecule being the early days primary replication machinery, information contents might have significantly lost and this will again raise a question on how similar or same species maintains identity?\r\n\r\nTransferring information outside of the nucleus is only required when there is a nucleus.\r\n\r\nTaken together these concepts, \u003cb\u003ewe need to revisit the origin of life in newer genetic terms.\u003c/b\u003e\r\n","created_at":"2015-09-16T17:43:27.824Z","updated_at":"2015-09-18T06:00:54.818Z","zenodo_id":61235,"doi":"http://dx.doi.org/10.5281/zenodo.31054","subject":null,"tags":["evolution","rna","dna","rna world","dna world","genetics"],"vote_count":1,"view_count":1,"score":1.1,"deleted":false,"muted":false,"tweeted":false,"attachment_file_name":null,"attachment_content_type":null,"attachment_file_size":null,"attachment_updated_at":null},{"id":407,"title":"Can DNA Rescue African Semi-legendary Chronicles?","sha":"dc0d8edc08f69eeb219f012a52304494","user_id":null,"state":"published","body":"Southern African social institutions are based on societal values, with folktales being used to teach moral values, preserve and perpetuate wisdom accumulated over many generations. The integration of folktales from oral to written phases has seen them being used in modern day schools as instructional strategies for teaching moral values and cultural competence. However, even though the art did not die with western conquest, folktales now face existential threats due to deculturation and western influence.\r\n\r\nThe solution might lie in the archiving these folktale files as physical Deoxyribonucleic acid (DNA) strands whose code can be read and converted back into a file’s original format as previously demonstrated in other studies. Algorithms for encoding these data in DNA strands can be developed by taking binary data of folktale files and converting them into DNA bases adenine (A), guanine (G), cytosine (C), and thymine (T), with each base being represented by a binary value. The DNA strands can then be synthesized and stored. To read the stored data, DNA is simply sequenced and the AGCT bases are converted back into binary. Hence DNA can be a perfect target for encoding, archiving and retrieving of the dying folktales for centuries. \r\n","created_at":"2017-10-01T21:41:19.370Z","updated_at":"2017-10-05T06:00:52.026Z","zenodo_id":1002368,"doi":"https://doi.org/10.5281/zenodo.1002368","subject":null,"tags":["folktales","dna","binary","african"],"vote_count":0,"view_count":1,"score":0.1,"deleted":false,"muted":false,"tweeted":true,"attachment_file_name":null,"attachment_content_type":null,"attachment_file_size":null,"attachment_updated_at":null}]