[{"id":381,"title":"Autism microglia research","sha":"3aa227bd98ac97fe9cd0f807c403cb73","user_id":null,"state":"published","body":"I am forming a group to submit a proposal to an NIH GRANT regarding Autism. The GRANT is R0. The deadline is 09/2019.  The Main idea is state of microglia on autism.  The theories behind area 2: white matter changes based on previous studies and microbiome dysbioses observed in autism.  There is a link between microbiome changes, histamine and microglia that i would like to study.  The group so far is composed by a pediatrics neurologist, epidemiologist and myself a pediatrician.  We are currently working on the proposal draft.  We are looking for someone with expertise on neuroscience specially on autism and nuclear medicine in autism for brain imaging studies.  The GRANT link is the following: https://grants.nih.gov/grants/guide/pa-files/PA-16-388.html","created_at":"2017-05-05T12:01:21.804Z","updated_at":"2017-05-06T06:01:02.128Z","zenodo_id":572267,"doi":"https://doi.org/10.5281/zenodo.572267","subject":null,"tags":["neuroscience","nih","grant"],"vote_count":0,"view_count":1,"score":0.1,"deleted":false,"muted":false,"tweeted":false,"attachment_file_name":null,"attachment_content_type":null,"attachment_file_size":null,"attachment_updated_at":null},{"id":1171,"title":"Relationship Between Violent Media and Individuals Demonstrating Aggressive Behavior ","sha":"d78c052067326e4f642c2a7b22598217","user_id":null,"state":"published","body":"The research's results vary on violent media's effect with some saying it has the effect of aggression while some say the opposite. However, although there have been multiple studies conducted about violent media's effect on the general population, there are a limited number of studies that focus on people who are already known to enjoy violence. Therefore, this brings the question, do people who are conducting violent behaviors for pleasure are also likely to become more violent when watching violent media? Or would the violent impulse decrease by playing violent video games or watching violent media as an alternative? This experiment can be conducted by using different methods such as computational models, or animal studying and observing the difference in neurotransmitters that are emitted, within the realm of ethical guidelines. \r\n\r\nThis experiment can show the broader effect of violent media and can help to create better regulation for it. ","created_at":"2023-11-17T04:38:27.121Z","updated_at":"2023-11-20T06:00:39.269Z","zenodo_id":10157862,"doi":"https://doi.org/10.5281/zenodo.10157862","subject":null,"tags":["media","psychology","neuroscience"],"vote_count":0,"view_count":1,"score":0.1,"deleted":false,"muted":false,"tweeted":false,"attachment_file_name":null,"attachment_content_type":null,"attachment_file_size":null,"attachment_updated_at":null},{"id":89,"title":"On centralized vs. decentralized neurotechnologies","sha":"80fe103e7e0fe456a227a195745b2a8b","user_id":335,"state":"published","body":"Neurotechnology is any technology developed to interface with brain function. It is a rapidly advancing area with important implications for the study of the brain and neurological disorders, as well as consumerization of the connectome and related neurocognitive processes. However, the topology of different neurotechnologies remains limited. One useful classification is between centralized and decentralized neurotechnologies. Centralized neurotechnologies are defined as having a direct input and/or output with the central nervous system (CNS). An example of this is a deep brain stimulation machine with inputs to the cortex or subcortical nuclei that is used to modulate neurotransmitter activity. Conversely, decentralized neurotechnologies do not share a direct link to CNS, but are designed to sense and/or modulate neural function. An example is a machine learning algorithm that uses realtime biological signals to predict seizure onset in epileptics and allow for preventative actions. Here, it is hypothesized that centralized and decentralized neurotechnologies vary along two important axes: the power to modulate neural function and the invasiveness of the technology. This classification system has important implications for (a) estimating the rate of neurotechnological proliferation and (b) generating ethical guidelines for both scientific research programs and consumer product development.","created_at":"2015-02-22T20:27:22.392Z","updated_at":"2015-02-25T20:42:10.984Z","zenodo_id":23310,"doi":"http://dx.doi.org/10.5281/zenodo.15594","subject":null,"tags":["neurotechnology","neuroscience","ai","brain","technology"],"vote_count":1,"view_count":1,"score":1.1,"deleted":false,"muted":false,"tweeted":true,"attachment_file_name":null,"attachment_content_type":null,"attachment_file_size":null,"attachment_updated_at":null},{"id":132,"title":"Neurocognitive basis of procrastination: the need for more startlines than deadlines","sha":"24c09b0302ea48aa27c848a8dabbbd88","user_id":190,"state":"published","body":"Research in cognitive psychology and neuroscience has provided evidence that goals are maintained by sustained goal representations in prefrontal cortex ([Miller \u0026 Cohen, 2001](http://dx.doi.org/10.1146/annurev.neuro.24.1.167)). Such goal representations contain details regarding the final goal state, in addition to various means to attain that goal. Goal representations are thought to be formed by co-activation of existing goal-relevant representations during goal creation ([O’Reilly \u0026 Frank, 2006](http://dx.doi.org/10.1162/089976606775093909)). Deadlines are goal-relevant representation that are often co-active with the decision to create a goal. It is therefore likely that deadlines are often embedded within a goal representation inappropriately, biasing goal-related actions to be carried out close to the emphasized time of the deadline (rather than spread out over the allotted time before the deadline). This would push the human brain’s control system toward procrastination. A possible work-around to this problem may be to set “startlines”, emphasizing when serious progress toward a goal (or subgoal) should have begun. Final deadlines will likely remain important in many domains, but one or more salient startlines may be useful for encouraging more on-time and higher quality goal-directed output.","created_at":"2015-03-26T19:59:12.250Z","updated_at":"2020-08-09T00:07:15.473Z","zenodo_id":25778,"doi":"http://dx.doi.org/10.5281/zenodo.16397","subject":null,"tags":["neuroscience","psychology","cognition","prefrontal cortex","cognitive control","procrastination","strategies"],"vote_count":4,"view_count":1,"score":4.1,"deleted":false,"muted":false,"tweeted":true,"attachment_file_name":null,"attachment_content_type":null,"attachment_file_size":null,"attachment_updated_at":null},{"id":133,"title":"Relationship between strokes and seizures","sha":"b7182ee5289b267cf912c5f80dbe2407","user_id":514,"state":"published","body":"During the four years that I cared for a person who had several strokes, I observed that the epileptic seizures which followed, often improved the condition caused by the strokes. It led me to consider, that epileptic seizures might be a self - defense - mechanism of the brain to counter the effects caused by a stroke, instead of being the result of damaged nerve connections as is commonly believed.\r\n\r\nExploring the possibility that indicators of a stroke (neurological, biochemical ...?) might be the trigger for some forms of epilepsy, could lead to new treatments.","created_at":"2015-03-27T16:33:06.483Z","updated_at":"2015-05-04T03:55:38.108Z","zenodo_id":25888,"doi":"http://dx.doi.org/10.5281/zenodo.16426","subject":null,"tags":["human brain","neuroscience","health"],"vote_count":3,"view_count":1,"score":3.1,"deleted":false,"muted":false,"tweeted":true,"attachment_file_name":null,"attachment_content_type":null,"attachment_file_size":null,"attachment_updated_at":null},{"id":250,"title":"Use Real-time MRI to Track Nitric Oxide in Our Brain","sha":"8f9809c2d7fb0c9661b15f59d827db6c","user_id":null,"state":"published","body":"We have already known that nitric oxide plays a important part in long-term potentiation as a neurotransmission in our brain, especially in hippocampus, and consequently plays an important role in both short-term memory and long-term memory. Thank to the physic basis of magnetic resonance imaging(MRI), any nucleus with a net nuclear spin, including nitrogen, could potentially be imaged with MRI, and the appearance of real-time MRI gives us a chance to obtain movies of the physiological activity in real time. Accordingly, we can use specialized real-time MRI technology to watch how nitric oxide act in our hippocampus or even in the whole brain when a human is learning something and trying to remember them. It is obvious that it can enrich our knowledge about how our memory is formed, or even how we study.","created_at":"2015-10-14T04:27:46.794Z","updated_at":"2015-10-23T06:00:41.026Z","zenodo_id":65589,"doi":"http://dx.doi.org/10.5281/zenodo.32532","subject":null,"tags":["neuroscience","human brain","nitric oxide","magnetic resonance imaging"],"vote_count":0,"view_count":1,"score":0.1,"deleted":false,"muted":false,"tweeted":false,"attachment_file_name":null,"attachment_content_type":null,"attachment_file_size":null,"attachment_updated_at":null}]