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Ideas tagged with ocd

Antidepressants, the gut microbiota, TRPA1 receptors and self-cooling.

Enhanced efflux pump expression and intracellular production of reactive oxygen species in gut bacteria has been observed following exposure for sixty days to several antidepressants, at clinically relevant concentrations.1. This pattern has been shown to be associated with increased microbiota...

By JOHN STEWART

Oxidative stress, MAOIs and OCD.

Cure of severe obsessional thinking by monoamine oxidase inhibitor* gave rise to “side” effects, meriting investigation as repeatedly linked to cure-points. Phenol-rich foods, particularly robusta coffees, release serotonin from gut enterochromaffin cells by phenol-generated free radicals. (Phen...

By JOHN STEWART

OCD, ST JOHN'S WORT AND IRON.

MAOI and St John's Wort treatments for OCD may have a similar radical-based mechanism. Six years' unrelieved total compulsive thinking was cured by the MAOI Phenelzine, with also a role for radical-releasing phenols which enter the CNS very little .1. (Journal of Brief Ideas article "Oxidative s...

By JOHN STEWART

OCD, TRPA1s, AND THE VAGAL FEAR PATHWAY.

As mentioned in articles in NPBR.1. and JBI.2., the crucial stage in MAOI and St John' s Wort OCD cures I have repeatedly found to be strong TRPA1 receptor activation by radicals, resulting in gut serotonin and CCK release. Matsuo et al.3. have pointed out that the TRPA1 vagal/trigeminal innate ...

By JOHN STEWART

OCD AND PYRUVATE DEHYDROGENASE

As set out in NPBR.1. and JBI.2., MAOI OCD cure involves gut TRPA1 activation by radicals*,and vagal/trigeminal change influencing the parabrachial and subthalamic nuclei.3. The subthalamic nucleus is implicated in OCD.4. with ventral subthalamic theta activity inversely-correlated with OCD seve...

By JOHN STEWART

Fenton reactions and OCD.

Fenton reactions and OCD. St John's Wort treatment (5x333mg pd) only became anti-OCD when ferrous fumarate was added.1. (2 to 5x14mg iron pd), suggesting radical releasing of serotonin was crucial, as on MAOIs.2. Gut Fenton reactions in the presence of free iron produce hydroxyl radicals, (ca...

By JOHN STEWART

"OCD, radicals and TRPA1 receptors".

Further to NPBR .1. and Journal of Brief Ideas papers on "Oxidative stress, MAOIs and OCD" and "OCD, St John's Wort and Iron", this paper concerns TRPA1 human gut receptors which respond to oxidative stress. The 1,2,3- and 1,2,4- benzenetriols are responsible for much of the gut release from cof...

By JOHN STEWART