Ideas tagged with somatic hypermutation

HIV Variation Driven By Somatic Hypermutation in Immunoglobulin Variable Genes

Here is an explanation for HIV variation: • HIV-1 infects many white cells - but particularly activated B cells in the early phase of infection setting up productive provirus in a significant fraction. • During somatic hypermutation of the HIV-infected B cell, the SHM machinery is recruited an...

By Edward Steele