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Ideas tagged with trpa1

Antidepressants, the gut microbiota, TRPA1 receptors and self-cooling.

Enhanced efflux pump expression and intracellular production of reactive oxygen species in gut bacteria has been observed following exposure for sixty days to several antidepressants, at clinically relevant concentrations.1. This pattern has been shown to be associated with increased microbiota...

By JOHN STEWART

OCD, TRPA1s, AND THE VAGAL FEAR PATHWAY.

As mentioned in articles in NPBR.1. and JBI.2., the crucial stage in MAOI and St John' s Wort OCD cures I have repeatedly found to be strong TRPA1 receptor activation by radicals, resulting in gut serotonin and CCK release. Matsuo et al.3. have pointed out that the TRPA1 vagal/trigeminal innate ...

By JOHN STEWART

"OCD, radicals and TRPA1 receptors".

Further to NPBR .1. and Journal of Brief Ideas papers on "Oxidative stress, MAOIs and OCD" and "OCD, St John's Wort and Iron", this paper concerns TRPA1 human gut receptors which respond to oxidative stress. The 1,2,3- and 1,2,4- benzenetriols are responsible for much of the gut release from cof...

By JOHN STEWART