[{"id":839,"title":"Neutrophils reduction by inducing autophagy may improve cancer treatment?","sha":"abc01374a98aa03745bf699a202f6e14","user_id":null,"state":"published","body":"Neutrophils are the key players of innate immune system that is well known to us. The information’s, which excite the new age researchers, is that the neutrophils may also be key players in cancer initiation and progression by several aspects. A pool of journal articles indicates that it has the potency to impacting tumor microenvironment to facilitating cancer growth. So here using some potential drugs those are capable of inducing autophagic cell death inside neutrophils will be a meaning full steps for cancer treatment as very recent research point out that neutrophils are died via autophagic cell death not by apoptosis. Thus by doing this we can control neutrophils numbers that may improve the patient’s health. Using this approach as combinational therapy with other anticancer therapy will also help in treatment. Obviously the drugs should be specific to the neutrophils. \r\nTo improve cancer treatments by this way we first have to standardize the neutrophils profiles for each cancer types, and we need to know more on how the tumor microenvironment converting the neutrophils. The use of these types of drugs needed where the neutrophils populations are found to acting for cancer.\r\n\r\n\r\n#https://www.nature.com/articles/s41420-018-0131-9  \r\n#https://academic.oup.com/burnstrauma/article/doi/10.1093/burnst/tkz001/5706919\r\n\r\nDeclaration:  It is not a research article. \r\n\r\n\r\n\r\n","created_at":"2021-03-14T12:26:56.574Z","updated_at":"2021-05-21T06:01:19.724Z","zenodo_id":4775102,"doi":"https://doi.org/10.5281/zenodo.4775102","subject":null,"tags":["neutrophils","autophagy","cancer treatment","combinational therapy"],"vote_count":0,"view_count":1,"score":0.1,"deleted":false,"muted":false,"tweeted":false,"attachment_file_name":null,"attachment_content_type":null,"attachment_file_size":null,"attachment_updated_at":null},{"id":851,"title":"Effect of PH on Copper hypertolarence: How does the Copper exporters of Staphylococcus aureus are maintaining its functionality within low PH of Phagosome ?","sha":"a4e70b4fae946a02ae95425d40099ebf","user_id":null,"state":"published","body":"\r\nWe know that, when any bacterium entered into our body as per the innate immunity phagocytic cells majorly macrophages activated and use copper into phagosome to kill the phagocytized bacterium. Unfortunately most of the bacterium is capable to escaping this due to presence of some genes which code for copper exporters on cell membrane, similarly for Staphylococcus aureus where it code for P1B-1-type ATPase and P1B-3-type ATPase which helped to lower the cytoplasmic copper concentration and enhanced survival. But my question is that how do the ion channels (copper exporters) are functioning well inside of phagosome ? The pH of early and late phagosome and phagolysosome are respectively 6.1–6.5; 5.5–6.0; and 5–5.5 and we know that different pH can alter protein shape, so what is the scenario for those exporters and how does its functioning well? The peptidoglycan barrier can be degraded by Lysozyme, so it is possible that the low pH can hamper the bacterium copper efflux efficiency or it is may also possible that they might have any protective mechanism. It is not measured yet so in different pH it can be done.\r\n\r\n\r\nReferences:\r\n\r\n1.\tDoi; 10.1128/mBio.00550-18\r\n2.\tDoi: 10.3389/fimmu.2017.01368\r\n\r\n\r\n@Eileen Uribe-Querol\r\n@ Carlos Rosales\r\n@Zapotoczna, Marta, et al. ","created_at":"2021-05-20T13:38:52.585Z","updated_at":"2021-09-02T06:00:41.922Z","zenodo_id":4898503,"doi":"https://doi.org/10.5281/zenodo.4898503","subject":null,"tags":["copper hypertolarence","copper exporters","phagosome ph","staphylococcus aureus"],"vote_count":3,"view_count":1,"score":3.1,"deleted":false,"muted":false,"tweeted":false,"attachment_file_name":"Effect_of_PH_on_Copper_hypertolarence_brief_Idea.pdf","attachment_content_type":"application/pdf","attachment_file_size":115231,"attachment_updated_at":"2021-05-20T13:38:52.439Z"},{"id":876,"title":"Hand sanitation during COVID 19 Could effective to reduce the gastrointestinal infections in India","sha":"3b7965dcd252bde01c0d542e1bc4cb01","user_id":null,"state":"published","body":"We all know that during COVID19 pandemic (1) we followed the safety guidelines and washed our hands properly with soap or any alcohol based sanitizer to prevent COVID 19 viral infection (2). COVID 19 pandemic created more cautiousness in terms of hand hygiene than we were previous. Scholarly articles already discussed the relation between hygiene and infection (3-5). It was reported that hand hygiene is effective in preventing gastrointestinal illnesses both developed and lesser-developed countries (3). Those who had never follows the hand hygiene (for home and street food), they are now maybe habituated and started to keep their hand hygiene. This may have impacted positively also against gastrointestinal infections. Possibility is that it may decreases the Infections (gastrointestinal specifically). But there is lacking of data and good survey based research. So, one can think of it. During statistical analysis researchers have to consider the COVID19 related gastrointestinal complications also. \r\n\r\n\r\nDeclaration: No conflict of Interest. This is not any research or review article. This is a personal view. \r\n\r\n\r\nReferences:\r\n\r\n1. https://www.who.int/health-topics/coronavirus#tab=tab_1 \r\n\r\n2.https://www.unicef.org/coronavirus/everything-you-need-know-about-washing-your-hands-protect-against-coronavirus-covid-19\r\n\r\n3. DOI: 10.2105/AJPH.2007.124610\r\n\r\n4. DOI: 10.1016/s1473-3099(02)00184-6\r\n\r\n5.https://www.who.int/southeastasia/news/detail/15-10-2020-handwashing-an-effective-tool-to-prevent-covid-19-other-diseases\r\n\r\n","created_at":"2021-08-19T13:47:19.725Z","updated_at":"2021-09-13T06:00:54.910Z","zenodo_id":5502226,"doi":"https://doi.org/10.5281/zenodo.5502226","subject":null,"tags":["hand sanitation","covid 19","gastrointestinal infections"],"vote_count":0,"view_count":1,"score":0.1,"deleted":false,"muted":false,"tweeted":false,"attachment_file_name":"Hand_sanitation_during_COVID_19_Could_effective_to_reduce_the_gastrointestinal_infections_in_India.pdf","attachment_content_type":"application/pdf","attachment_file_size":292278,"attachment_updated_at":"2021-08-19T13:47:19.691Z"}]