[{"id":148,"title":"ImpL2 homolog Peroxidasin as an active participant in human neoplasm. ","sha":"3517024c4d7a7be413f4adf87840725f","user_id":283,"state":"published","body":"Rationalizing on the work published by Young Kwon et al [Cell](http://www.cell.com/developmental-cell/abstract/S1534-5807%2815%2900114-8) could peroxidasin play an active role in cancer via pathways of insulin/IGF signaling? Peroxidasin is cited as ImpL2 homolog in humans, but what makes peroxidasin an interesting molecule is the fact that it has been shown to play a part in different pathways associated with human neoplasm [Nucleic Acids Research](http://nar.oxfordjournals.org/content/43/D1/D204). To resolve the question/s of the role played by peroxidasin -if any- some possible paths could be explored: How is peroxidasin expressed in human cancer? Is peroxidasin a detectable seric protein, if so, is it elevated in cancer patients? Could an elevated expression of peroxidasin be linked with cancer-induced cachexia?  ","created_at":"2015-04-17T18:54:22.041Z","updated_at":"2015-04-18T06:00:23.565Z","zenodo_id":27258,"doi":"http://dx.doi.org/10.5281/zenodo.16930","subject":null,"tags":["cancer metabolism","peroxidasin"],"vote_count":0,"view_count":1,"score":0.1,"deleted":false,"muted":false,"tweeted":false,"attachment_file_name":null,"attachment_content_type":null,"attachment_file_size":null,"attachment_updated_at":null},{"id":78,"title":"Cancer cell nuclear expulsion: a possible mechanism of survival, and metastasis capability. ","sha":"b566367fae06afe6914bece416ea75cd","user_id":283,"state":"published","body":"A very interesting and novel experiment was carried out by Florina Bojin et al [Wiley](http://onlinelibrary.wiley.com/doi/10.1111/jcmm.12271/abstract). Constructing on this published work, I propose a novel survival mechanism of the cancer cell, and a new metastasis mechanism. Giving that cancer cells are known for their survival capabilities, could a nuclear expulsion -produced by stress, either biochemical, mechanical or nutritional- be used as survival mechanism, and, or a seeding action? The questions are many, but the answers could bring a new understanding of what exactly constitutes a cell or could a nucleus of of a cell -cancer cell- survive without its host cell? I propose a further investigation of the possibility that a cancer cell nucleus could be a seeding apparatus for metastases. Would a nucleus be able to ''high-jack''  another cell -if the nucleus survives the expulsion-? Is there an immune response to an ejected nucleus? I think the first steps are to confirm the existence of nuclear expulsion In Vivo, the viability of the ejected nuclei, and the possibility of ''nuclear cellular high-jacking''.\r\nThank you.     ","created_at":"2015-02-20T21:35:36.809Z","updated_at":"2015-02-26T11:52:06.861Z","zenodo_id":23227,"doi":"http://dx.doi.org/10.5281/zenodo.15562","subject":null,"tags":["science","cancer","molecularbiology","mechanism","cellular"],"vote_count":3,"view_count":1,"score":3.1,"deleted":false,"muted":false,"tweeted":false,"attachment_file_name":null,"attachment_content_type":null,"attachment_file_size":null,"attachment_updated_at":null}]