JOHN STEWART's ideas
Oxidative stress, MAOIs and OCD.
Cure of severe obsessional thinking by monoamine oxidase inhibitor* gave rise to “side” effects, meriting investigation as repeatedly linked to cure-points. Phenol-rich foods, particularly robusta coffees, release serotonin from gut... continue reading
MAOI and St John's Wort treatments for OCD may have a similar radical-based mechanism. Six years' unrelieved total compulsive thinking was cured by the MAOI Phenelzine, with also a role for radical-releasing phenols which enter the CNS very little... continue reading
"OCD, radicals and TRPA1 receptors".
Further to NPBR .1. and Journal of Brief Ideas papers on "Oxidative stress, MAOIs and OCD" and "OCD, St John's Wort and Iron", this paper concerns TRPA1 human gut receptors which respond to oxidative stress. The 1,2,3- and 1,2,4- benzenetriols are... continue reading
Fenton reactions and OCD.
St John's Wort treatment (5x333mg pd) only became anti-OCD when ferrous fumarate was added.1. (2 to 5x14mg iron pd), suggesting radical releasing of serotonin was crucial, as on MAOIs.2. Gut Fenton reactions in the... continue reading
OCD, TRPA1s, AND THE VAGAL FEAR PATHWAY.
As mentioned in articles in NPBR.1. and JBI.2., the crucial stage in MAOI and St John' s Wort OCD cures I have repeatedly found to be strong TRPA1 receptor activation by radicals, resulting in gut serotonin and CCK release. Matsuo et al.3. have... continue reading
OCD AND PYRUVATE DEHYDROGENASE
As set out in NPBR.1. and JBI.2., MAOI OCD cure involves gut TRPA1 activation by radicals*,and vagal/trigeminal change influencing the parabrachial and subthalamic nuclei.3. The subthalamic nucleus is implicated in OCD.4. with ventral subthalamic... continue reading
Testing the role of radicals in sleep deprivation`s antidepressant effect.
Recent research on sleep deprivation(SD) has demonstrated in the mouse large free radical increases after two days SD, selectively in the small intestine (and large).1. This timescale closely parallels that of the quick, hard to sustain, human... continue reading
Antidepressants, the gut microbiota, TRPA1 receptors and self-cooling.
Enhanced efflux pump expression and intracellular production of reactive oxygen species in gut bacteria has been
observed following exposure for sixty days to several antidepressants, at clinically relevant concentrations.1. This pattern has been... continue reading
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