HIV Variation Driven By Somatic Hypermutation in Immunoglobulin Variable Genes
Here is an explanation for HIV variation:
• HIV-1 infects many white cells - but particularly activated B cells in the early phase of infection setting up productive provirus in a significant fraction.
• During somatic hypermutation of the HIV-infected B cell, the SHM machinery is recruited and targets both the integrated transcriptionally active HIV-1 provirus and the endogenous immunoglobulin VDJ locus.
• The mutant B cell survivors will produce a single mutant antibody but also numerous mutated LTR bounded HIV-1 variants (some active but most inactive, even empty virions) .
Published: 26 Mar, 2015