Antidepressants, the gut microbiota, TRPA1 receptors and self-cooling.
By JOHN STEWART
Enhanced efflux pump expression and intracellular production of reactive oxygen species in gut bacteria has been
observed following exposure for sixty days to several antidepressants, at clinically relevant concentrations.1. This pattern has been shown to be associated with increased microbiota antibiotic resistance, but from another point of view this chronic effect of antidepressant use may over time increase radical levels in the aerobic (small) intestine by altering the gut microbiota, leading to OCD-curative radical action at gut TRPA1 receptors, releasing serotonin from enterochromaffin cells,(linked to anxiety modulation.2.), as outlined previously.3.
The peripheral release of serotonin and CCK due to gut TRPA1 activation causes blood flow changes repeatedly seen just prior to the onset of cure-points on MAOI treatment, most strikingly alternating hot, high blood flow red ears (followed by bilateral). This may relate to a reinstatement of more effective self-cooling systems, as possible defects of self-cooling systems and raised temperatures are positively correlated with depression severity in a large-scale recent study.4. The complex role of the vagus in metabolic regulation, and the need for vagal change in OCD cure referred to in earlier papers make this pattern understandable.5.
.1.ProcNatlAcadSciUSA.2023.Jan31;120(5):e2208344120.
.2.Nature.2023.Apr;616(7955):137-142.
.3.Neurology,Psychiatry,andBrainResearch5(4):181,8(4):185,10(4):149.Journal of Brief Ideas."Oxidative stress,
MAOIs and OCD","OCD,radicals and TRPA1 receptors".
.4.Nature.Scientific Reports.2024.5 Feb.
.5.AnnalsofNYAcademyofSciences.2019.1454(1):42-55.
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